The sub-project within the EU-funded Doctoral Network ViroiDoc focuses on the exogenous applications of RNA molecules for the non-transgenic control of resistance to viroid infections. Coding and non-coding regulatory RNAs are used to specifically modulate gene expression in plants. Various RNA species are used to strengthen the natural defense of plants against viroids.
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The expansion of the RNA toolbox to include mRNA and antisense circulator RNA (caRNA) enables more precise gene regulations and intrinsic modifications, including the integration of CRISPR/Cas components. These innovative approaches not only improve the control of viroid infections, but also offer a wide range of applications in plant defense and sustainable agriculture.
ViroiDoc is a Marie Sklodowska-Curie Doctoral Network funded by the European Union. Within this network, our sub-project focuses on the exogenous application of RNA molecules for the non-transgenic control of viroid infections in plants, with a particular emphasis on hop (Humulus lupulus). Both coding and non-coding regulatory RNAs are used to specifically modulate plant gene expression and to enhance natural defense mechanisms against viroids. Expanding the RNA toolbox to include not only RNAi/dsRNA. mRNA and antisense circular RNA (caRNA) enables for further gene regulations, including the transient delivery of CRISPR/Cas components. These innovative RNA-based approaches improve strategies for controlling viroid infections but also open ip broad perspectives for plant protection and sustainable agriculture.
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