The sub-project within the EU-funded Doctoral Network ViroiDoc focuses on the exogenous applications of RNA molecules for the non-transgenic control of resistance to viroid infections. Coding and non-coding regulatory RNAs are used to specifically modulate gene expression in plants. Various RNA species are used to strengthen the natural defense of plants against viroids.
The expansion of the RNA toolbox to include mRNA and antisense circulator RNA (caRNA) enables more precise gene regulations and intrinsic modifications, including the integration of CRISPR/Cas components. These innovative approaches not only improve the control of viroid infections, but also offer a wide range of applications in plant defense and sustainable agriculture.
ViroiDoc is a Marie Sklodowska-Curie Doctoral Network funded by the European Union. Within this network, our sub-project focuses on the exogenous application of RNA molecules for the non-transgenic control of viroid infections in plants, with a particular emphasis on hop (Humulus lupulus). Both coding and non-coding regulatory RNAs are used to specifically modulate plant gene expression and to enhance natural defense mechanisms against viroids. Expanding the RNA toolbox to include not only RNAi/dsRNA. mRNA and antisense circular RNA (caRNA) enables for further gene regulations, including the transient delivery of CRISPR/Cas components. These innovative RNA-based approaches improve strategies for controlling viroid infections but also open ip broad perspectives for plant protection and sustainable agriculture.
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