The aim of the hoRtikultrNA project is to advance RNA-based spray technologies for their broad application in sustainable plant protection in horticulture. In close collaboration with partners from polymer chemistry, we are developing innovative encapsulation strategies that enhance the stability and rain fastness of RNA-based active ingredients. A key focus is the use of stimuli-responsive micro gel formulations that protect RNA molecules until the reach the target organism such as butterfly caterpillars. Biobased and biodegradable microgels derived from polysaccharides, including chitosan, enable prolonged persistence of RNA on crop plants (e.g. potato) while offering flexible functionalization to address diverse challenges related to stability, delivery, uptake and release. Throughout the project, we systematically integrate the latest research on resistance management and ecotoxicological safety into formulation development. This ensures that the resulting technologies are both effective and environmentally responsible.