The development and application of sprayable non-coding and coding RNAs enables the targeted manipulation of plant gene expression. For example, exogenously applied dsRNA can induce gene silencing of endogenous or foreign mRNA transcripts in plants and their pathogens (see RNAo projects=, resulting in RNA interference-mediated disease resistance. Plants can also take up exogenously applied mRNA and translate it into proteins. This new method of spray-induced gene expression enables the synthesis of any proteins in plants without the need to produce genetically modified plants. 

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However, the use of RNAs in research and application requires the development of efficient RNA delivery strategies. The uptake of RNA by the cuticle and its transport into the cell are of high importance. In order to maximize the efficiency of exogenously applied RNAs, we are working with partners ni the EXmRNA project to develop chitosan-based colonial micro gels as RNA carriers that can be modified to have specific structural and functional properties that significantly improve the uptake and release of RNA in cells.

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Further information can be found here: CodeChi - DFG Priority Programme SPP 2416

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